AFM of tissue sections is a useful complementary tool as a biomedical marker

The aim of the study was to demonstrate a good diagnostic potential of atomic force microscopy (AFM) in tracking morphological changes in the extracellular matrix (ECM) of connective tissue due to pathological processes. Here we summarize our experience in AFM application in a number of biomedical studies on the connective tissue disease, both for research and clinical purposes. AFM has been shown to reveal visible deviations from the normal...