HLA Alleles and CYP 2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians

Volume: 105, Issue: 2, Pages: 476 - 485
Published: Sep 30, 2018
Abstract
To develop a pre-emptive genetic test that comprises multiple predisposing alleles for the prevention of phenytoin-related severe cutaneous adverse reactions (SCARs), three sets of patients with phenytoin-SCAR and drug-tolerant controls from Taiwan, Thailand, and Japan, were enrolled for this study. In addition to cytochrome P450 (CYP)2C9*3, we found that HLA-B*13:01, HLA-B*15:02, and HLA-B*51:01 were significantly associated with phenytoin...
Paper Details
Title
HLA Alleles and CYP 2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians
Published Date
Sep 30, 2018
Volume
105
Issue
2
Pages
476 - 485
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