Internalization capabilities of gold-198 nanoparticles: Comparative evaluation of effects of chitosan agent on cellular uptake into MCF-7

In this study, internalization of positively charged chitosan-coated nanoparticles (198[email protected]) on MCF-7 cells was investigated by γ-ray spectroscopy and then statistically compared to that of 198Au and negatively charged citrate-stabilized nanoparticles (198AuNPs). Sub-50 nm 198[email protected] had a higher internalization compared to 198Au and 198AuNPs (p < 0.05). More cellular uptake of 198[email protected] means a higher dose of...