Periventricular nodular heterotopia in 22q11.2 deletion and frontal lobe migration

Objective We aimed to delineate the distribution of periventricular nodular heterotopia ( PNH ) in patients with 22q11.2 microdeletion syndrome (22q11.2 DS ) and place this in the context of other genetic forms of PNH . Methods We retrospectively analyzed brain imaging and postmortem data available for adult patients with 22q11.2 DS . We included only those with good quality MRI data ( n = 29) in addition to two patients with PNH identified...