Experimental evaluation of solvent elution strength in reversed-phase thin-layer chromatography on RP2 and RP8 plates

The eluotropic strength on RP2 and RP8 plates was investigated for 7 chromatographic grade solvents miscible with water as a diluent (acetone, acetonitrile, dioxane, ethanol, isopropanol, methanol, and tetrahydrofuran) as well as for water itself. Thirty-five model compounds were used as a test set in the investigation. The use of a modern chemometric mixture design concept allowed separate estimation of each solvent effect from the other...