Radiology

Neuroscience

Depression (economics)

Subiculum

Macroeconomics

Magnetic resonance imaging

Hippocampal formation

Cognition

Psychology

Economics

Dentate gyrus

Hippocampus

Major depressive disorder

Neuroimaging

Medicine

Biological Psychiatry

Hippocampal volume reduction is the most replicated finding in neuroimaging studies of major depressive disorder (MDD). Varying hippocampal volume definition is a well-established problem in this field. Given that hippocampal function can be mapped onto anatomically defined substructures and that detailed examination of substructure volumes is now possible, we examined different hippocampal composite measures in MDD to look for hippocampal markers of MDD.

The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression