Diagnostic accuracy of a new ex vivo confocal laser scanning microscope compared to H&E‐stained paraffin slides for micrographic surgery of basal cell carcinoma

For safe excision of malignant skin tumours, complete negative surgical margins are mandatory. The gold standard for analysis is frozen sections or paraffin-embedded haematoxylin and eosin (H&E)-stained slides. The production of H&E-stained slides is time-consuming (>20 h) while wounds remain unclosed. An upcoming method is confocal laser scanning microscopy (CLSM), a technique that scans unfixed fresh tissue rapidly.Evaluation of the process to...