Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
Abstract
Intratumoral heterogeneity in cancers arises from genomic instability and epigenomic plasticity and is associated with resistance to cytotoxic and targeted therapies. We show here that cell-state heterogeneity, defined by differentiation-state marker expression, is high in triple-negative and basal-like breast cancer subtypes, and that drug tolerant persister (DTP) cell populations with altered marker expression emerge during treatment with a...
Paper Details
Title
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
Published Date
Sep 19, 2018
Journal
Volume
9
Issue
1
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