5‐hydroxytryptophan attenuates imiquimod‐induced psoriasiform dermatitis probably through inhibition of IL‐17A production and keratinocyte activation

Psoriasis is a chronic autoimmune disease with keratinocyte activation and lymphocyte infiltration in the skin. Our previous study found that 5‐hydroxytryptophan (5( OH )Trp), a tryptophan metabolite, alleviated collagen‐induced arthritis and suppressed cytokine production. In this study, we evaluated the effects of 5( OH )Trp in a mouse model for psoriasiform dermatitis, induced by imiquimod ( IMQ ). We showed that 5( OH )Trp significantly...