Temporal dynamics of bacteria-plasmid coevolution under antibiotic selection
Abstract
Horizontally acquired genes can be costly to express even if they encode useful traits, such as antibiotic resistance. We previously showed that when selected with tetracycline, Escherichia coli carrying the tetracycline-resistance plasmid RK2 evolved mutations on both replicons that together provided increased tetracycline resistance at reduced cost. Here we investigate the temporal dynamics of this intragenomic coevolution. Using genome...
Paper Details
Title
Temporal dynamics of bacteria-plasmid coevolution under antibiotic selection
Published Date
Sep 12, 2018
Journal
Volume
13
Issue
2
Pages
559 - 562
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