Gadolinium Deposition in Brain: Current Scientific Evidence and Future Perspectives

In the past 4 years, a number of publications described a dose-dependent deposition of gadolinium in the brain both in adults and children, seen as high signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images. Postmortem human or animal studies have confirmed gadolinium deposition in these areas of T1-hyperintensity, raising new concerns regarding the safety of gadolinium-based contrast agents (GBCAs)....