Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
Abstract
Understanding mechanisms of late/acquired cancer immunotherapy resistance is critical to improve outcomes; cellular immunotherapy trials offer a means to probe complex tumor-immune interfaces through defined T cell/antigen interactions. We treated two patients with metastatic Merkel cell carcinoma with autologous Merkel cell polyomavirus specific CD8+ T cells and immune-checkpoint inhibitors. In both cases, dramatic remissions were associated...
Paper Details
Title
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
Published Date
Sep 24, 2018
Journal
Volume
9
Issue
1
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