Biomimetic water channels: general discussion

Published on Sep 26, 2018in Faraday Discussions4.008
· DOI :10.1039/C8FD90020E
Marc Baaden38
Estimated H-index: 38
,
Mihail Barboiu51
Estimated H-index: 51
+ 24 AuthorsMartin Vögele8
Estimated H-index: 8
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Abstract
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#1Martín Calvelo (University of Santiago de Compostela)H-Index: 7
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Self-assembling cyclic peptide nanotubes can form nanopores when they are inserted in lipid bilayers, acting as ion and/or water permeable channels. In order to improve the versatility of these systems, it is possible to specifically design cyclic peptides with a combination of natural and non-natural amino acids, enabling the control of the nature of the inner cavity of the channels. Here, the behavior of two types of self-assembling peptide motifs, alternating α-amino acids with γ- or δ-aminoc...
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#1Li-Bo Huang (SYSU: Sun Yat-sen University)H-Index: 5
#2Maria Di VincenzoH-Index: 3
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Natural Aquaporin (AQP) channels are efficient water translocating proteins, rejecting ions. Inspired by this masterpiece of nature, Artificial Water Channels (AWCs) with controlled functional structures, can be potentially used to mimic the AQPs to a certain extent, offering flexible avenues toward biomimetic membranes for water purification. The objective of this paper is to trace the historical development and significant advancements of current reported AWCs. Meanwhile, we attempt to reveal ...
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#1Woochul Song (University of Texas at Austin)H-Index: 11
#2Himanshu Joshi (UIUC: University of Illinois at Urbana–Champaign)H-Index: 14
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Artificial water channels are synthetic molecules that aim to mimic the structural and functional features of biological water channels (aquaporins). Here we report on a cluster-forming organic nanoarchitecture, peptide-appended hybrid[4]arene (PAH[4]), as a new class of artificial water channels. Fluorescence experiments and simulations demonstrated that PAH[4]s can form, through lateral diffusion, clusters in lipid membranes that provide synergistic membrane-spanning paths for a rapid and sele...
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#1Xavier Martinez (University of Paris)
#2Arthur HardiagonH-Index: 1
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In biology, metabolite transport across cell membranes occurs through natural channels and pores. Artificial ion-channel architectures represent potential mimics of natural ionic conduction. Many such systems were produced leading to a remarkable set of alternative artificial ion-channels. Far less advances were achieved in the area of synthetic biomimetic water channels, even though they could improve our understanding of the natural function of protein channels and may provide new strategies t...
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#1Woochul Song (PSU: Pennsylvania State University)H-Index: 11
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Artificial water channels (AWCs) are synthetic mimics of biological water channel proteins, aquaporins. They combine the characteristic features of aquaporins, including a transmembrane orientation in biomimetic membrane matrices and the possibility of combining high water permeability with high water/solute selectivity, with higher processability and stability compared to protein channels. AWCs have thus emerged as a platform for biomimetic membrane development. During the last few years, remar...
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Biomimetic and bioinspired membranes have emerged as an innovative platform for water purification and aqueous separations. They are inspired by the exceptional water permeability (∼109 water molecules per second per channel) and perfect selectivity of biological water channels, aquaporins. However, only few successes have been reported for channel-based membrane fabrication due to inherent challenges of realizing coherence between channel design at the angstrom level and development of scalable...
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