Blood lysosphingolipids accumulation in patients with parkinson's disease with glucocerebrosidase 1 mutations
Abstract
Glucocerebrosidase 1 mutations, the most common genetic contributor to Parkinson's disease (PD), have been associated with decreased glucocerebrosidase enzymatic activity in PD patients with glucocerebrosidase 1 mutations (glucocerebrosidase 1-PD). However, it is unknown whether this decrease in enzymatic activity leads to lysosphingolipid accumulations.The levels of hexosylsphingosines, globotriaosylsphingosine, sphingomyelin, and...
Paper Details
Title
Blood lysosphingolipids accumulation in patients with parkinson's disease with glucocerebrosidase 1 mutations
Published Date
Aug 1, 2018
Journal
Volume
33
Issue
8
Pages
1325 - 1330
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