A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma
Abstract
Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their resistance to therapy. Analyses revealed that recurrent GBMs have increased tension and express high levels of glycoproteins that increase the bulkiness of the glycocalyx. Studies showed that a bulky glycocalyx potentiates integrin mechanosignalling and tissue tension and promotes a...
Paper Details
Title
A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma
Published Date
Sep 10, 2018
Journal
Volume
20
Issue
10
Pages
1203 - 1214
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