Original paper

ATG5 is required for B cell polarization and presentation of particulate antigens

Volume: 15, Issue: 2, Pages: 280 - 294
Published: Sep 22, 2018
Abstract
The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5 (autophagy related 5) contributes to BCR polarization after stimulation and internalization into LAMP1 (lysosomal-associated membrane protein 1)+ and major histocompatibility complex class II (MHC-II)+ compartments. BCR polarization is crucial in the context of immobilized antigen processing....
Paper Details
Title
ATG5 is required for B cell polarization and presentation of particulate antigens
Published Date
Sep 22, 2018
Journal
Volume
15
Issue
2
Pages
280 - 294
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