A novel pH-responsive quaternary ammonium chitosan-liposome nanoparticles for periodontal treatment

Published on May 15, 2019in International Journal of Biological Macromolecules5.162
· DOI :10.1016/J.IJBIOMAC.2018.09.057
Fang Hu4
Estimated H-index: 4
(Qingdao University),
Zhongzheng Zhou11
Estimated H-index: 11
(Ocean University of China)
+ 6 AuthorsXiguang Chen61
Estimated H-index: 61
(Ocean University of China)
Abstract The aim of this study was to evaluate the antibacterial activity and cytocompatibility of novel pH-activated nanoparticles (NPs) in vitro and in vivo. The NPs were synthesized from a quaternary ammonium chitosan, i.e., N,N,N-trimethyl chitosan, a liposome, and doxycycline (TMC-Lip-DOX NPs). The cytocompatibility of the NPs was evaluated. The TMC-Lip-DOX NPs achieved superb inhibition of free mixed bacteria and biofilm formation. They also showed excellent biocompatibility with human periodontal ligament fibroblasts. Animal experiments showed that the NPs strongly inhibited biofilm formation and prevented alveolar bone absorption in vivo. All the results indicate that the TMC-Lip-DOX NPs have good potential for use in the treatment of periodontal and other inflammatory diseases.
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