Defects in interferon pathways as potential biomarkers of sensitivity to oncolytic viruses
Abstract
Increased sensitivity of cancer cells to viruses is a prerequisite for the success of oncolytic virotherapy. One of the major causes of such a phenotype is the disruption of innate antiviral defenses associated with dysfunction of type 1 interferons (IFNs) that permits unlimited replication of viruses in cancer cells. Defects in IFN pathways help cancer progression by providing additional advantages to tumor cells. However, while these defects...
Paper Details
Title
Defects in interferon pathways as potential biomarkers of sensitivity to oncolytic viruses
Published Date
Sep 13, 2018
Journal
Volume
28
Issue
6
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