Four drug-sensitive subunits are required for maximal effect of a voltage sensor–targeted KCNQ opener

Volume: 150, Issue: 10, Pages: 1432 - 1443
Published: Aug 30, 2018
Abstract
KCNQ2-5 (Kv7.2–Kv7.5) channels are strongly influenced by an emerging class of small-molecule channel activators. Retigabine is the prototypical KCNQ activator that is thought to bind within the pore. It requires the presence of a Trp side chain that is conserved among retigabine-sensitive channels but absent in the retigabine-insensitive KCNQ1 subtype. Recent work has demonstrated that certain KCNQ openers are insensitive to mutations of this...
Paper Details
Title
Four drug-sensitive subunits are required for maximal effect of a voltage sensor–targeted KCNQ opener
Published Date
Aug 30, 2018
Volume
150
Issue
10
Pages
1432 - 1443
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