Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
Abstract
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell RNA-sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Here, we show that intercellular heterogeneity of gene expression programs within each tumor is variable and largely correlates with clonality of inferred genomic copy number changes, suggesting that...
Paper Details
Title
Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
Published Date
Sep 4, 2018
Journal
Volume
9
Issue
1
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