Pre-Clinical Activity of Tipifarnib in Cutaneous T-Cell Lymphoma

Cutaneous T-cell lymphoma (CTCL) is a rare form of non-Hodgkin lymphoma characterized by malignant infiltration of skin-homing T-cells manifesting clinically as patches and plaques on the skin. The most common type of CTCL is an indolent, skin-limited form called mycosis fungoides (MF) which may progress to an aggressive leukemic variant, Sézary Syndrome (SS). As there are few effective therapies available for advanced-stage CTCL, we sought to...