Neutrophils induce smooth muscle hyperplasia via neutrophil elastase‐induced FGF‐2 in a mouse model of asthma with mixed inflammation

Bronchial asthma is traditionally characterized by chronic allergic inflammation, including eosinophilia and elevated Th2 cytokines. Recently, IL-17-derived neutrophil infiltration was shown to correlate with asthma severity and airway remodelling.To investigate the role of IL-17-derived neutrophils in airway remodelling in chronic bronchial asthma.We utilized house dust mite antigen-induced mouse models of asthma. Intranasal sensitization and...