Enhanced activity of an ADAMTS‐13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke

Volume: 16, Issue: 11, Pages: 2289 - 2299
Published: Nov 1, 2018
Abstract
Essentials•ADAMTS13 requires a substrate‐induced conformational change to attain full activity in vitro.•The efficacy of wild type ADAMTS13 in models of thrombosis/stroke may be enhanced by pre‐activation.•A pre‐activated ADAMTS13 variant exhibits enhanced proteolysis of platelet agglutinates.•This ADAMTS13 variant is protective in a murine model of stroke at a lower dose than WT ADAMTS13.AcknowledgementsThis work was funded by grants from the...
Paper Details
Title
Enhanced activity of an ADAMTS‐13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke
Published Date
Nov 1, 2018
Volume
16
Issue
11
Pages
2289 - 2299
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.