Original paper

Copper(I)-Catalyzed Oxydifluoroalkylation of Alkenes: A Route to Functionalization of Lactones

Volume: 20, Issue: 17, Pages: 5149 - 5152
Published: Aug 24, 2018
Abstract
An efficient copper(I)-catalyzed oxydifluoroalkylation of unsaturated carboxylic acids has been developed under mild reaction conditions. Various α-bromodifluoromethyl substituted heterocycles, esters, amides, and ketones were successfully employed as the CF2 source. This cost-effective copper(I) catalysis provides expedient access to high valued lactones with ample substrate scope, wide functional group tolerance, and up to 98%...
Paper Details
Title
Copper(I)-Catalyzed Oxydifluoroalkylation of Alkenes: A Route to Functionalization of Lactones
Published Date
Aug 24, 2018
Volume
20
Issue
17
Pages
5149 - 5152
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