Geology

Computer science

Catalysis

Oceanography

Surface modification

Physical chemistry

Polymer

Organic chemistry

Scope (computer science)

Reaction conditions

Substrate (aquarium)

Chemistry

Metallurgy

Materials science

Programming language

Functional group

Yield (engineering)

Combinatorial chemistry

Copper

Organic Letters

An efficient copper(I)-catalyzed oxydifluoroalkylation of unsaturated carboxylic acids has been developed under mild reaction conditions. Various α-bromodifluoromethyl substituted heterocycles, esters, amides, and ketones were successfully employed as the CF2 source. This cost-effective copper(I) catalysis provides expedient access to high valued lactones with ample substrate scope, wide functional group tolerance, and up to 98% yield.

Copper(I)-Catalyzed Oxydifluoroalkylation of Alkenes: A Route to Functionalization of Lactones