Immuno-Oncology: Emerging Targets and Combination Therapies
Abstract
Host immunity recognizes and eliminates most early tumor cells, yet immunological checkpoints, exemplified by CTLA-4, PD-1, and PD-L1, pose a significant obstacle to effective antitumor immune responses. T-lymphocyte co-inhibitory pathways influence intensity, inflammation and duration of antitumor immunity. However, tumors and their immunosuppressive microenvironments exploit them to evade immune destruction. Recent PD-1 checkpoint inhibitors...
Paper Details
Title
Immuno-Oncology: Emerging Targets and Combination Therapies
Published Date
Aug 23, 2018
Journal
Volume
8
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Notes
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