Cancer genetics, precision prevention and a call to action
Abstract
More than 15 years have passed since the identification, through linkage, of 'first-wave' susceptibility genes for common cancers (BRCA1, BRCA2, MLH1 and MSH2). These genes have strong frequency-penetrance profiles, such that the associated clinical utility probably remains relevant regardless of the context of ascertainment. 'Second-wave' genes, not tractable by linkage, were subsequently identified by mutation screening of candidate genes...
Paper Details
Title
Cancer genetics, precision prevention and a call to action
Published Date
Aug 29, 2018
Journal
Volume
50
Issue
9
Pages
1212 - 1218
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Notes
History