Expanding the medicinal chemistry synthetic toolbox
Abstract
The key objectives of medicinal chemistry are to efficiently design and synthesize bioactive compounds that have the potential to become safe and efficacious drugs. Most medicinal chemistry programmes rely on screening compound collections populated by a range of molecules derived from a set of known and robust chemistry reactions. Analysis of the role of synthetic organic chemistry in subsequent hit and lead optimization efforts suggests that...
Paper Details
Title
Expanding the medicinal chemistry synthetic toolbox
Published Date
Aug 24, 2018
Volume
17
Issue
10
Pages
709 - 727
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