Superstructure-Dependent Loading of DNA Origami Nanostructures with a Groove-Binding Drug

Volume: 3, Issue: 8, Pages: 9441 - 9448
Published: Aug 20, 2018
Abstract
DNA origami nanostructures are regarded as powerful and versatile vehicles for targeted drug delivery. So far, DNA origami-based drug delivery strategies mostly use intercalation of the therapeutic molecules between the base pairs of the DNA origami’s double helices for drug loading. The binding of nonintercalating drugs to DNA origami nanostructures, however, is less studied. Therefore, in this work, we investigate the interaction of the drug...
Paper Details
Title
Superstructure-Dependent Loading of DNA Origami Nanostructures with a Groove-Binding Drug
Published Date
Aug 20, 2018
Journal
Volume
3
Issue
8
Pages
9441 - 9448
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