Structural Insights into Polyhydroxyalkanoates Biosynthesis

Polyhydroxyalkanoates (PHAs) are natural polyesters consisting of various hydroxyalkanoates (HAs) and have attracted much attention as a feasible substitute to conventional petroleum-based plastics. The PHA biosynthetic pathway consists of three enzymes: acetyl-CoA acetyltransferase (PhaA), acetoacetyl-CoA reductase (PhaB), and PHA synthase (PhaC). PhaA catalyzes the two-step condensation reaction of acetyl-CoA to acetoacetyl-CoA, and the size...