Structural Insights into Polyhydroxyalkanoates Biosynthesis.

Published on Oct 1, 2018in Trends in Biochemical Sciences14.732
· DOI :10.1016/J.TIBS.2018.08.005
Hye-Young Sagong8
Estimated H-index: 8
(KNU: Kyungpook National University),
Hyeoncheol Francis Son10
Estimated H-index: 10
(KNU: Kyungpook National University)
+ 2 AuthorsKyung-Jin Kim26
Estimated H-index: 26
(KNU: Kyungpook National University)
Polyhydroxyalkanoates (PHAs) are diverse biopolyesters produced by numerous microorganisms and have attracted much attention as a substitute for petroleum-based polymers. Despite several decades of study, the detailed molecular mechanisms of PHA biosynthesis have remained unknown due to the lack of structural information on the key PHA biosynthetic enzyme PHA synthase. The recently determined crystal structure of PHA synthase, together with the structures of acetyl-coenzyme A (CoA) acetyltransferase and reductase, have changed this situation. Structural and biochemical studies provided important clues for the molecular mechanisms of each enzyme as well as the overall mechanism of PHA biosynthesis from acetyl-CoA. This new information and knowledge is expected to facilitate production of designed novel PHAs and also enhanced production of PHAs.
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