Re-examining age-related differences in white matter microstructure with free-water corrected diffusion tensor imaging
Abstract
Diffusion tensor imaging (DTI) has been used extensively to investigate white matter (WM) microstructural changes during healthy adult aging. However, WM fibers are known to shrink throughout the lifespan, leading to larger interstitial spaces with age. This could allow more extracellular free water molecules to bias DTI metrics, which are relied upon to provide WM microstructural information. Using a cohort of 212 participants, we demonstrate...
Paper Details
Title
Re-examining age-related differences in white matter microstructure with free-water corrected diffusion tensor imaging
Published Date
Aug 1, 2018
Journal
Volume
71
Pages
161 - 170
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