Activating Autophagy Enhanced the Antitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E

Antibody drug conjugate (ADC) showed potent therapeutic efficacy in several types of cancers. The role of autophagy in anti-tumor effects of ADC remains unclear. In this study, a novel ADC, Rituximab-monomethyl auristatin E (MMAE) with a Val-Cit cleavable linker, was designed to investigate its therapeutic efficacy against Non-Hodgkin Lymphoma (NHL) as well as the underlying mechanisms. Our results showed that Rituximab-MMAE elicited...