Abstract LB-061: Systematic, network-based, comparative analysis of differential mechanisms of action of lanreotide and octreotide in neuroendocrine tumor derived cell lines

Lanreotide and octreotide are somatostatin receptor (SSTR) agonists thought to exhibit overlapping Mechanism of Action (MoA), despite small differences in their SSTRs affinity and differential PK response in vivo [1]. To systematically and quantitatively assess both concentration- and time-dependent MoA differences at the molecular level —by characterizing the full protein repertoire that mediates the compound's pharmacological effects— we...