Detection and Characterization of Renal Stones by Using Photon-Counting-based CT.

Published on Aug 7, 2018in Radiology7.931
· DOI :10.1148/RADIOL.2018180126
Roy P. Marcus2
Estimated H-index: 2
(Mayo Clinic),
Roy P. Marcus14
Estimated H-index: 14
(Mayo Clinic)
+ 7 AuthorsCynthia H. McCollough76
Estimated H-index: 76
The evaluated photon-counting–detector CT system has the potential to improve the automatic characterization of small stones (≤3 mm).
📖 Papers frequently viewed together
114 Citations
31 Citations
#1Andrea Ferrero (Mayo Clinic)H-Index: 8
#2Ralf Gutjahr (TUM: Technische Universität München)H-Index: 7
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 5 authors...
Rational and Objectives This study aims to investigate the performance of a whole-body, photon-counting detector (PCD) computed tomography (CT) system in differentiating urinary stone composition. Materials and Methods Eighty-seven human urinary stones with pure mineral composition were placed in four anthropomorphic water phantoms (35–50 cm lateral dimension) and scanned on a PCD-CT system at 100, 120, and 140 kV. For each phantom size, tube current was selected to match CTDIvol (volume CT dose...
7 CitationsSource
#1Rolf Symons (NIH: National Institutes of Health)H-Index: 17
#2Amir Pourmorteza (NIH: National Institutes of Health)H-Index: 18
Last. David A. BluemkeH-Index: 138
view all 13 authors...
This feasibility study demonstrated good diagnostic quality, noise power spectrum, and lung nodule contrast-to-noise ratio with dose-reduced photon-counting detector chest CT compared with those attained with conventional energy-integrating detector CT.
34 CitationsSource
#1Zhicong Yu (Mayo Clinic)H-Index: 11
#2Shuai LengH-Index: 53
Last. Cynthia H. McColloughH-Index: 76
view all 7 authors...
A research photon-counting computed tomography (CT) system that consists of an energy-integrating detector (EID) and a photon-counting detector (PCD) was installed in our laboratory. The scanning fields of view of the EID and PCD at the isocenter are 500 and 275 mm, respectively. When objects are larger than the PCD scanning field of view, a data-completion scan (DCS) using the EID subsystem is needed to avoid truncation artifacts in PCD images. The goals of this work were to (1) find the impact...
29 CitationsSource
#1Ralf Gutjahr (TUM: Technische Universität München)H-Index: 7
#2Ahmed F. HalaweishH-Index: 16
Last. Cynthia H. McColloughH-Index: 76
view all 10 authors...
ObjectivesThe purpose of this work was to measure and compare the iodine contrast-to-noise ratio (CNR) between a commercial energy-integrating detector (EID) computed tomography (CT) system and a photon-counting detector (PCD) CT scanner capable of human imaging at clinical dose rates, as well as to
86 CitationsSource
#1Zhicong Yu (Mayo Clinic)H-Index: 11
#2Shuai Leng (Mayo Clinic)H-Index: 53
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 11 authors...
This study evaluated the conventional imaging performance of a research whole-body photon-counting CT system and investigated its feasibility for imaging using clinically realistic levels of x-ray photon flux. This research system was built on the platform of a 2nd generation dual-source CT system: one source coupled to an energy integrating detector (EID) and the other coupled to a photon-counting detector (PCD). Phantom studies were conducted to measure CT number accuracy and uniformity for wa...
114 CitationsSource
#1Amir Pourmorteza (NIH: National Institutes of Health)H-Index: 18
#2Rolf Symons (NIH: National Institutes of Health)H-Index: 17
Last. David A. Bluemke (NIH: National Institutes of Health)H-Index: 138
view all 10 authors...
The photon-counting detector system showed equivalent performance to clinical energy-integrating detectors when the abdomen was evaluated in a conventional scanning mode with the added advantage of providing spectral information that may be used for material decomposition.
99 CitationsSource
#1William E. HaleyH-Index: 23
#2El-Sayed H. IbrahimH-Index: 14
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 6 authors...
Dual-energy computed tomography (DECT) has recently been suggested as the imaging modality of choice for kidney stones due to its ability to provide information on stone composition. Standard postprocessing of the dual-energy images accurately identifies uric acid stones, but not other types. Cystine stones can be identified from DECT images when analyzed with advanced postprocessing. This case report describes clinical implications of accurate diagnosis of cystine stones using DECT.
3 CitationsSource
#1Sebastian Faby (DKFZ: German Cancer Research Center)H-Index: 4
#2Stefan Kuchenbecker (DKFZ: German Cancer Research Center)H-Index: 6
Last. Marc Kachelrieß (DKFZ: German Cancer Research Center)H-Index: 29
view all 7 authors...
Purpose: To study the performance of different dual energy computed tomography (DECT) techniques, which are available today, and future multi energy CT (MECT) employing novel photon counting detectors in an image-based material decomposition task. Methods: The material decomposition performance of different energy-resolved CT acquisition techniques is assessed and compared in a simulation study of virtual non-contrast imaging and iodine quantification. The material-specific images are obtained v...
110 CitationsSource
#1Soyeon Ahn (Seoul National University Bundang Hospital)H-Index: 37
#2Seong Ho Park (UOU: University of Ulsan)H-Index: 66
Last. Kyoung Ho LeeH-Index: 26
view all 3 authors...
Definitive demonstration of similarity between compared groups requires a separate statistical logic known as equivalence/noninferiority testing.
89 CitationsSource
#1Robert P. Hartman (Mayo Clinic)H-Index: 25
#2Akira Kawashima (Mayo Clinic)H-Index: 50
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
view all 8 authors...
Computed tomography (CT) imaging is a vital tool in the evaluation of suspected abnormalities of the kidneys and urinary tract. In recent years, the development of dual-energy CT (DECT) platforms and innovative scanning techniques has provided additional tools for the diagnosis and characterization of renal masses, urolithiasis, and disorders of the uroepithelium. This article discusses the technical aspects of dual-energy scanning and its specific utility in imaging of the kidneys and urinary t...
48 CitationsSource
Cited By17
#1Achim Byl (DKFZ: German Cancer Research Center)
#2Laura Klein (DKFZ: German Cancer Research Center)H-Index: 1
Last. Marc Kachelrieß (Heidelberg University)H-Index: 3
view all 10 authors...
Purpose Metal artifacts can drastically reduce the diagnostic value of CT images. Even the state-of-the-art algorithms cannot remove them completely. Photon counting CT inherently provides spectral information, similar to dual energy CT. Many applications, such as material decomposition, are not possible when metal artifacts are present. Our aim is to develop a prior-based metal artifact reduction specifically for photon counting CT that can correct each bin image individually or their combinati...
#1Dominik Nakhostin (UZH: University of Zurich)H-Index: 1
#2Thomas Sartoretti (UZH: University of Zurich)H-Index: 1
Last. André Euler (UZH: University of Zurich)H-Index: 8
view all 7 authors...
PURPOSE To compare noise texture and accuracy to differentiate uric acid from non-uric acid urinary stones among four different single-source and dual-source DECT approaches in an ex vivo phantom study. METHODS Thirty-two urinary stones embedded in gelatin were mounted on a Styrofoam disk and placed into a water-filled phantom. The phantom was imaged using four different DECT approaches: (A) dual-source DECT (DS-DE); (B) 1st generation split-filter single-source DECT (SF1-TB); (C) 2nd generation...
#1Jiří FerdaH-Index: 14
#2Tomas VendisH-Index: 1
Last. Hynek MírkaH-Index: 9
view all 10 authors...
Abstract Objectives to assess the feasibility of CT with an integrated photon-counting-detector system (PC-CT) in the body imaging of clinical patients. Methods 120 examinations using photon counting detector CT were evaluated in six groups: 1/ a standard-dose lung, 2/ low-dose lung, 3/ ultra-high resolution (UHR) lung, 4/ standard-dose abdominal, 5/ lower-dose abdominal, 6/ UHR abdominal CTA. All CT examinations were performed on a single-source prototype device equipped with a photon counting ...
#1E. Wehrse (DKFZ: German Cancer Research Center)H-Index: 1
#2Laura Klein (DKFZ: German Cancer Research Center)H-Index: 3
Last. Stefan Sawall (DKFZ: German Cancer Research Center)H-Index: 14
view all 12 authors...
Over the last decade, a fundamentally new type of computed tomography (CT) detectors has proved its superior capabilities in both physical and preclinical evaluations and is now approaching the stage of clinical practice. These detectors are able to discriminate single photons and quantify their energy and are hence called photon-counting detectors. Among the promising benefits of this technology are improved radiation dose efficiency, increased contrast-to-noise ratio, reduced metal artifacts, ...
1 CitationsSource
#1Alan C. KwanH-Index: 11
#2Amir PourmortezaH-Index: 18
Last. Joao A.C. LimaH-Index: 124
view all 5 authors...
Impending major hardware advances in cardiac CT include three areas: ultra-high-resolution (UHR) CT, photon-counting CT, and phase-contrast CT. Cardiac CT is a particularly demanding CT application that requires a high degree of temporal resolution, spatial resolution, and soft-tissue contrast in a moving structure. In this review, cardiac CT is used to highlight the strengths of these technical advances. UHR CT improves visualization of calcified and stented vessels but may result in increased ...
2 CitationsSource
#1Hao Gong (Mayo Clinic)H-Index: 8
#2Shengzhen Tao (Mayo Clinic)H-Index: 13
Last. Shuai Leng (Mayo Clinic)H-Index: 53
view all 6 authors...
PURPOSE To develop a convolutional neural network (CNN) that can directly estimate material density distribution from multi-energy computed tomography (CT) images without performing conventional material decomposition. METHODS The proposed CNN (denoted as Incept-net) followed the general framework of encoder-decoder network, with an assumption that local image information was sufficient for modeling the nonlinear physical process of multi-energy CT. Incept-net was implemented with a customized l...
2 CitationsSource
#2Hongkai YangH-Index: 4
Last. Yuxiang Xing (THU: Tsinghua University)H-Index: 18
view all 4 authors...
With the growing technology of photon-counting detectors (PCD), spectral CT is an important topic for its potential in material differentiation. However, direct reconstruction of the detected spectrum without any compensation will lead to inaccurate results due to some non-ideal factors such as cross talk and pulse pile-up in the detectors. Conventional methods try to model these factors using calibrations and make compensations accordingly, but the results depend on the model calibration accura...
#1Thomas Flohr (Siemens)H-Index: 86
#2Martin Petersilka (Siemens)H-Index: 9
Last. Bernhard Schmidt (Siemens)H-Index: 50
view all 6 authors...
Photon-counting detectors are a promising new technology for computed tomography (CT) systems. They provide energy-resolved CT data at very high spatial resolution without electronic noise and with improved tissue contrasts. This review article gives an overview of the principles of photon-counting detector CT, of potential clinical benefits and limitations, and of the experience gained so far in pre-clinical installations.
2 CitationsSource
#1Shengzhen Tao (Mayo Clinic)H-Index: 13
#2Jeffrey F. Marsh (Mayo Clinic)H-Index: 1
Last. Shuai Leng (Mayo Clinic)H-Index: 53
view all 7 authors...
Multi-energy CT imaging of large patients with conventional dual-energy (DE)-CT using an energy-integrating-detector (EID) is challenging due to photon starvation-induced image artifacts, especially in lower tube potential (80-100 kV) images. Here, we performed phantom experiments to investigate the performance of DECT for morbidly obese patients, using an iodine and water material decomposition task as an example, on an emulated dual-source (DS)-photon-counting-detector (PCD)-CT, and compared i...
2 CitationsSource
#2Hongkai YangH-Index: 4
Last. Yuxiang Xing (THU: Tsinghua University)H-Index: 18
view all 4 authors...
With the growing technology of photon-counting detectors (PCD), spectral CT is a widely concerned topic which has the potential of material differentiation. However, due to some non-ideal factors such as cross talk and pulse pile-up of the detectors, direct reconstruction from detected spectrum without any corrections will get a wrong result. Conventional methods try to model these factors using calibration and make corrections accordingly, but depend on the preciseness of the model. To solve th...