Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents
Abstract
To prevent implant failure due to fibrosis is a major objective in glaucoma research. The present study investigated the antifibrotic effects of paclitaxel (PTX), caffeic acid phenethyl ester (CAPE), and pirfenidone (PFD) coated microstent test specimens in a rat model. Test specimens based on a biodegradable blend of poly(4-hydroxybutyrate) biopolymer and atactic poly(3-hydroxybutyrate) (at.P(3HB)) were manufactured, equipped with local drug...
Paper Details
Title
Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents
Published Date
Aug 31, 2018
Journal
Volume
38
Issue
4
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