Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits.

Volume: 50, Issue: 9, Pages: 1318 - 1326
Published: Aug 13, 2018
Abstract
We developed a likelihood-based approach for analyzing summary-level statistics and external linkage disequilibrium information to estimate effect-size distributions of common variants, characterized by the proportion of underlying susceptibility SNPs and a flexible normal-mixture model for their effects. Analysis of results available across 32 genome-wide association studies showed that, while all traits are highly polygenic, there is wide...
Paper Details
Title
Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits.
Published Date
Aug 13, 2018
Volume
50
Issue
9
Pages
1318 - 1326
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