Effects of arginine-based surface modifications of liposomes for drug delivery in Caco-2 colon carcinoma cells
Abstract
Liposomal encapsulation of chemotherapeutics improves circulation time and decreases off-target effects through the enhanced permeability and retention (EPR) effect. Improving the efficacy of these drug carriers through surface modification could benefit patients. A library of arginine derivatives was conjugated to liposomes through carbodiimide chemistry. Both unmodified and modified liposomes were loaded with doxorubicin and exposed to Caco-2...
Paper Details
Title
Effects of arginine-based surface modifications of liposomes for drug delivery in Caco-2 colon carcinoma cells
Published Date
Nov 1, 2018
Volume
139
Pages
8 - 14
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