Multiplexed protein maps link subcellular organization to cellular states
Abstract
Obtaining highly multiplexed protein measurements across multiple length scales has enormous potential for biomedicine. Here, we measured, by iterative indirect immunofluorescence imaging (4i), 40-plex protein readouts from biological samples at high-throughput from the millimeter to the nanometer scale. This approach simultaneously captures properties apparent at the population, cellular, and subcellular levels, including microenvironment, cell...
Paper Details
Title
Multiplexed protein maps link subcellular organization to cellular states
Published Date
Aug 3, 2018
Journal
Volume
361
Issue
6401
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