Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors
Abstract
Monoacylglycerol lipase (MAGL) is the enzyme hydrolyzing the endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid and glycerol. Therefore, MAGL is implicated in many physiological processes involving the regulation of the endocannabinoid system and eicosanoid network. MAGL inhibition represents a potential therapeutic target for many diseases, including cancer. Nowadays, most MAGL inhibitors inhibit this enzyme by an...
Paper Details
Title
Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors
Published Date
Sep 1, 2018
Volume
157
Pages
817 - 836
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