The small heat shock protein HSPB1 protects mice from sepsis

Volume: 8, Issue: 1
Published: Aug 21, 2018
Abstract
In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1 −/− mice is unremarkable. To determine the impact of HSPB1 in injury, HSPB1 −/− and wild type (WT) mice were subjected to cecal ligation and puncture, a model of polymicrobial sepsis. Ten-day mortality was significantly higher in HSPB1 −/− mice following the...
Paper Details
Title
The small heat shock protein HSPB1 protects mice from sepsis
Published Date
Aug 21, 2018
Volume
8
Issue
1
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