Icariin loaded-hollow bioglass/chitosan therapeutic scaffolds promote osteogenic differentiation and bone regeneration

The design and fabrication of therapeutic bone scaffolds that combine bioactive materials with osteoinductive drugs is a promising strategy for bone regeneration. Herein, we firstly developed icariin loaded-hollow bioglass/chitosan (ICA/HBG/CS) therapeutic scaffolds to treat critical-sized bone defects. The HBG/CS hybrid scaffolds possessed three-dimensional (3D) interconnected macropores with sizes of approximately 200 μm, which not only...