Local metabolic hypothesis is not sufficient to explain coronary autoregulatory behavior
Abstract
The local metabolic hypothesis proposes that myocardial oxygen tension determines the degree of autoregulation by increasing the production of vasodilator metabolites as perfusion pressure is reduced. Thus, normal physiologic levels of coronary venous PO2, an index of myocardial oxygenation, are proposed to be required for effective autoregulation. The present study challenged this hypothesis through determination of coronary responses to...
Paper Details
Title
Local metabolic hypothesis is not sufficient to explain coronary autoregulatory behavior
Published Date
Aug 2, 2018
Journal
Volume
113
Issue
5
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