Abstract 1873: Preclinical activity of tipifarnib in cutaneous T-cell lymphoma

Cutaneous T-cell lymphoma (CTCL) is a rare form of non-Hodgkin lymphoma characterized by malignant infiltration of skin-homing CD4+ T-cells, manifesting clinically as patches and plaques on the skin (Wong HK, et al. Br J Haematol 2011). The disease will often progress from an indolent skin-limited form, Mycosis Fungoides (MF), to an aggressive leukemic variant, Sezary Syndrome (SS) (Kohnken R, et al. Curr Hematol Malig Rep 2016). As there are...