Vemurafenib

Melanoma

Dabrafenib

Biology

Gene

Phosphorylation

Kinase

Chemistry

Serine

Trametinib

V600E

Mutation

MAPK/ERK pathway

Signal transduction

Mitogen-activated protein kinase kinase

Protein kinase A

Metastatic melanoma

Cancer research

Scaffold protein

Biochemistry

c-Raf

Pharmacological Research

The Ras-Raf-MEK-ERK signal transduction cascade is arguably the most important oncogenic pathway in human cancers. Ras-GTP promotes the formation of a…

Targeting oncogenic Raf protein-serine/threonine kinases in human cancers