m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
Abstract
N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer. To study the roles of m6A mRNA methylation in cell proliferation and tumorigenicity, we investigated human endometrial cancer in which a hotspot R298P mutation is present in a key component of the methyltransferase complex (METTL14). We found that about 70% of endometrial tumours exhibit...
Paper Details
Title
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
Published Date
Aug 27, 2018
Journal
Volume
20
Issue
9
Pages
1074 - 1083
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