Stage (stratigraphy)

Chemistry

Materials science

Positron emission tomography

Preclinical imaging

Physics

Positron

Geology

Electron

Biotechnology

Nuclear medicine

Biology

Radiochemistry

Emission computed tomography

Brain positron emission tomography

In vivo

Positron emission

Paleontology

Nuclear physics

Medicine

Angewandte Chemie International Edition

Peptides are often ideal ligands for diagnostic molecular imaging due to their ease of synthesis and tuneable targeting properties. However, labelling unmodified peptides with 18 F for positron emission tomography (PET) imaging presents a number of challenges. Here we show the combination of photoactivated sodium decatungstate and [18 F]-N-fluorobenzenesulfonimide effects site-selective 18 F-fluorination at the branched position in leucine residues in unprotected and unaltered peptides. This streamlined process provides a means to directly convert native peptides into PET imaging agents under mild aqueous conditions, enabling rapid discovery and development of peptide-based molecular imaging tools.

Site‐Selective, Late‐Stage C−H <sup>18</sup>F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging

Site‐Selective, Late‐Stage C−H 18F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging

Site‐Selective, Late‐Stage C−H ¹⁸F‐Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging