Functionalized gold nanoparticles for drug delivery applications

Published on Jan 1, 2018in Materials Today: Proceedings
· DOI :10.1016/J.MATPR.2018.06.030
S. Thambiraj6
Estimated H-index: 6
(University of Madras),
Soundararajan Hema3
Estimated H-index: 3
(University of Madras),
D. Ravi Shankaran9
Estimated H-index: 9
(University of Madras)
Abstract Gold nanoparticles (AuNPs) have been receiving great attention over the years due to their unique optical, electrical and biological properties. The functionalization of AuNPs is an important research interest owing to its potential application in various areas including biomedical, defense, food and environmental. Herein, we demonstrate a simple and effective method for the synthesis of functionalized AuNPs. Gold nanoparticles were synthesized by chemical reduction method using trisodium citrate as capping and reducing agent. The synthesized AuNPs were functionalized with poly (ethylene glycol) (PEG) and folic acid (FA). Further, an anticancer drug, Docetaxel (DTX) has been attached with the PEG functionalized AuNPs. The physicochemical properties of the functionalized PEG-FA-DTX-AuNPs were studied by various techniques including, UV-visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Field-emission scanning electron microscope (FE-SEM) and Energy dispersive X-ray spectroscopy (EDS). The average size of the synthesized AuNPs was found to be 21.75 nm. The functionalized AuNPs has been evaluated for its cell proliferation and cellular uptake properties. The results suggest that the functionalized AuNPs possess good potential for targeted drug delivery and bio-imaging applications.
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Submitted in fulfillment of the requirement for degree Master of Applied Sciences in Chemistry, Durban University of Technology, Durban, South Africa, 2019.