Methicillin-resistant Staphylococcus aureus

Bacteria

Biology

Gene

Immunology

Leukocidin

Genetics

Staphylococcus aureus

Biochemistry

Virulence

Pharmacology

Phytoalexin

Resveratrol

Hemolysis

Hemolysin

Chemistry

Microbiology

Emerging Microbes & Infections

Resveratrol is a natural phytoalexin. In recent studies, it has been shown to have beneficial effects on cardiovascular disease and cancer and has been deemed to have effective antiviral and immunomodulatory activities. Methicillin-resistant Staphylococcus aureus is a multidrug-resistant pathogen associated with skin and soft tissue infections. Alpha-hemolysin is known to play a key role in the symptoms caused by S. aureus, and the saeRS two-component system has been shown to be a major regulatory system of S. aureus virulence. The present study was designed to determine the effect of subinhibitory concentrations of resveratrol on the production of alpha-hemolysin in S. aureus. The effect of resveratrol on the transcription of S. aureus was studied by transcriptome sequencing. A total of 760 genes with >2-fold changes in expression were selected, including 479 upregulated genes and 281 downregulated genes. On the basis of transcriptome sequencing, the expression of alpha-hemolysin in the S. aureus strains of ...

Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in <i>Staphylococcus aureus</i> isolates by downregulating <i>saeRS</i>

Subinhibitory concentrations of resveratrol reduce alpha-hemolysin production in Staphylococcus aureus isolates by downregulating saeRS