Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma

Volume: 24, Issue: 23, Pages: 5977 - 5989
Published: Dec 1, 2018
Abstract
Purpose: null Translocation renal cell carcinoma (tRCC) represents a rare subtype of kidney cancer associated with various TFE3, TFEB, or MITF gene fusions that are not responsive to standard treatments for RCC. Therefore, the identification of new therapeutic targets represents an unmet need for this disease. null Experimental Design: null We have established and characterized a tRCC patient-derived xenograft, RP-R07, as a novel preclinical...
Paper Details
Title
Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma
Published Date
Dec 1, 2018
Volume
24
Issue
23
Pages
5977 - 5989
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