Biology

Receptor tyrosine kinase

Vascular endothelial growth factor C

Vascular endothelial growth factor B

VEGF receptors

Vascular endothelial growth factor A

Lymphatic system

Immunology

Vascular endothelial growth factor

Signal transduction

Cell biology

Lymphatic Endothelium

Cancer research

Development

ABSTRACT Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety of cells and they bind to their cognate tyrosine kinase VEGF receptors (VEGFRs) in endothelial cells to elicit various downstream effects. In recent years, there has been tremendous progress in elucidating different VEGF/VEGFR signaling functions in both the blood and lymphatic vascular systems. Here, and in the accompanying poster, we present key elements of the VEGF/VEGFR pathway and highlight the classical and newly discovered functions of VEGF signaling in blood and lymphatic vessel development and pathology.

Vascular endothelial growth factor signaling in development and disease