Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study.

Published on Jul 30, 2018in Diabetes Care16.019
· DOI :10.2337/DC18-0185
Angela C. Shore58
Estimated H-index: 58
(NIHR: National Institute for Health Research),
Helen M. Colhoun79
Estimated H-index: 79
(Edin.: University of Edinburgh)
+ 19 AuthorsJan Nilsson115
Estimated H-index: 115
(Lund University)
OBJECTIVE Cardiovascular disease (CVD) risk prediction represents an increasing clinical challenge in the treatment of diabetes. We used a panel of vascular imaging, functional assessments, and biomarkers reflecting different disease mechanisms to identify clinically useful markers of risk for cardiovascular (CV) events in subjects with type 2 diabetes (T2D) with or without manifest CVD. RESEARCH DESIGN AND METHODS The study cohort consisted of 936 subjects with T2D recruited at four European centers. Carotid intima-media thickness and plaque area, ankle-brachial pressure index, arterial stiffness, endothelial function, and circulating biomarkers were analyzed at baseline, and CV events were monitored during a 3-year follow-up period. RESULTS The CV event rate in subjects with T2D was higher in those with ( n = 440) than in those without ( n = 496) manifest CVD at baseline (5.53 vs. 2.15/100 life-years, P 2 [16.1–92.2] vs. 19.5 mm 2 [9.5–40.5], P = 0.01). Conventional risk factors, as well as measurements of arterial stiffness and endothelial reactivity, were not associated with CV events. CONCLUSIONS Our observations demonstrate that markers of inflammation and endothelial stress reflect CV risk in subjects with T2D with manifest CVD, whereas the risk for CV events in subjects with T2D without manifest CVD is primarily related to the severity of atherosclerosis.
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